ADS Biotechnology, Ltd. has obtained the following issued patents through an exclusive license to the University of Toledo-developed technologies that are being developed as ADS4203.
Albumin-Based Colloid Composition and Method of Use in Treating Hypovolemia and Multiorgan Dysfunction
Abstract: A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
- U.S. 7,037,895 B2
- Provisional Filed: March 27, 2001
- Issued: May 2, 2006
- Expires: March 27, 2021
Albumin-Based Colloid Composition and Method of Use in Treating Hypovolemia and Multiorgan Dysfunction
This patent is a continuation of U.S. 7,037,895 B2, providing additional claims.
- U.S. 7,348,312 B2 (Continuation of U.S. 7,037,895 B2)
- Provisional Filed: March 27, 2001
- Issued: March 25, 2008
- Expires: March 27, 2021
Albumin-Based Colloid Composition and Method of Use in Treating Hypovolemia and Multiorgan Dysfunction
This patent is a division of U.S. 7,348,312 B2, providing additional claims.
- U.S. 7,605,130 B2 (Division of U.S. 7,037,895 B2)
- Provisional Filed: March 27, 2001
- Issued: October 20, 2009
- Expires: March 27, 2021
Albumin-based colloid (PEG-Alb with Cys-34 preserved as a thiol)
Abstract: A composition comprising a polyethylene glycol-albumin colloid composition having Cys-34 preserved as a thiol (PEG-AlbCys-34), wherein PEG-AlbCys-34 has a hydrodynamic radius that is sufficiently large to preclude the composition from leaking through a patient’s capillaries and is 13 fold larger than the hydrodynamic radius of an albumin protein, wherein the PEG-AlbCys-34 is human albumin or bovine serum albumin modified with an indicator reagent; wherein the indicator reagent is a first dye having an emission and excitation spectra and a second dye having an emission and excitation spectra wherein the emission and excitation spectra of the second dye is distinct from that of the first dye.
- USP 7,345,150
- Provisional Filed: March 27, 2001
- Issued: May 2, 2006
- Expires: March 27, 2021
Albumin-Based Colloid Composition Having at Least One Protected Thiol Region, and Methods of Use
Abstract: A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions such as capillary leak syndrome and shock, are disclosed.
- U.S. 7,884,068
- Provisional Filed: March 26, 2002
- Issued: February 8, 2011
- Expires: February 8, 2028